Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice

Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced analgesia. The pathophysiological role of this process is unknown. We aimed to investigate whether sigma-1 antagonism reduces inflammatory pain throug...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Tejada, Miguel A., Montilla-García, Angeles, Cronin, Shane J., Cikes, Domagoj, Sánchez-Fernández, Cristina, González-Cano, Rafael, Ruiz-Cantero, M. Carmen, Penninger, Josef M., Vela, José M., Baeyens, José M., Cobos, Enrique J.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2017
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547590/
https://ncbi.nlm.nih.gov/pubmed/28716934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620068114
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