Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia

Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3). No effective FGFR3-targeted therapies for ACH are currently available. By drug repositioning strategies, we identified that meclozine, whic...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Matsushita, Masaki, Esaki, Ryusaku, Mishima, Kenichi, Ishiguro, Naoki, Ohno, Kinji, Kitoh, Hiroshi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547068/
https://ncbi.nlm.nih.gov/pubmed/28785080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07044-8
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