Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by activating mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. We identified that meclizine hydrochloride inhibited FGFR3 signaling in various chondrocytic cells and promoted longitudinal bone growth in...

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Publicat a:PLoS One
Autors principals: Kitoh, Hiroshi, Matsushita, Masaki, Mishima, Kenichi, Nagata, Tadashi, Kamiya, Yasunari, Ueda, Kohei, Kuwatsuka, Yachiyo, Morikawa, Hiroshi, Nakai, Yasuhiro, Ishiguro, Naoki
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153885/
https://ncbi.nlm.nih.gov/pubmed/32282831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229639
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