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Bioinspired Total Synthesis and Human Proteasome Inhibitory Activity of (−)-Salinosporamide A, (−)-Homosalinosporamide A, and Derivatives Obtained via Organonucleophile Promoted Bis-Cyclizations
A full account of concise, enantioselective syntheses of the anticancer agent (−)-salinosporamide A and derivatives, including (−)-homosalinosporamide, is described that was inspired by biosynthetic considerations. The brevity of the synthetic strategy stems from a key bis-cyclization of a (β)-keto...
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| Publicat a: | J Org Chem |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5546919/ https://ncbi.nlm.nih.gov/pubmed/21047113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo101638r |
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