In vitro and in vivo evaluation of SN-38 nanocrystals with different particle sizes

7-Ethyl-10-hydroxycamptothecin (SN-38) is a potent broad-spectrum antitumor drug derived from irinotecan hydrochloride (CPT-11). Due to its poor solubility and instability of the active lactone ring, its clinical use is significantly limited. As one of the most promising formulations for poorly wate...

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Detalles Bibliográficos
Publicado en:Int J Nanomedicine
Main Authors: Chen, Min, Li, Wanqing, Zhang, Xun, Dong, Ye, Hua, Yabing, Zhang, Hui, Gao, Jing, Zhao, Liang, Li, Ying, Zheng, Aiping
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2017
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546766/
https://ncbi.nlm.nih.gov/pubmed/28814865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S133816
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