Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR

Diversification of RNA-targeted scaffolds offers great promise in the search for selective ligands of therapeutically relevant RNA such as HIV-1 TAR. We herein report the establishment of amiloride as a novel RNA-binding scaffold along with synthetic routes for combinatorial C(5)- and C(6)-diversifi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Medchemcomm
Päätekijät: Patwardhan, Neeraj N., Ganser, Laura R., Kapral, Gary J., Eubanks, Christopher S., Lee, Janghyun, Sathyamoorthy, Bharathwaj, Al-Hashimi, Hashim M., Hargrove, Amanda E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Royal Society of Chemistry 2017
Aiheet:
Chemistry
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546750/
https://ncbi.nlm.nih.gov/pubmed/28798862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00729e
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