The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination

Hyperthermia has a number of biological effects that sensitize tumors to radiotherapy in the range between 40-44 °C. One of these effects is heat-induced degradation of BRCA2 that in turn causes reduced RAD51 focus formation, which results in an attenuation of DNA repair through homologous recombina...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: van den Tempel, Nathalie, Laffeber, Charlie, Odijk, Hanny, van Cappellen, Wiggert A., van Rhoon, Gerard C., Franckena, Martine, Kanaar, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546504/
https://ncbi.nlm.nih.gov/pubmed/28574821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17861
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