Synergistic targeting of malignant pleural mesothelioma cells by MDM2 inhibitors and TRAIL agonists

Malignant Pleural Mesothelioma (MPM) is a chemoresistant tumor characterized by low rate of p53 mutation and upregulation of Murine Double Minute 2 (MDM2), suggesting that it may be effectively targeted using MDM2 inhibitors. In the present study, we investigated the anticancer activity of the MDM2...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Urso, Loredana, Cavallari, Ilaria, Silic-Benussi, Micol, Biasini, Lorena, Zago, Giulia, Calabrese, Fiorella, Conte, Pier Franco, Ciminale, Vincenzo, Pasello, Giulia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546476/
https://ncbi.nlm.nih.gov/pubmed/28562336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17790
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