Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients

Allergy, pancreatitis and thrombosis are common side-effects of childhood acute lymphoblastic leukemia (ALL) treatment that are associated with the use of asparaginase (ASNase), a key component in most ALL treatment protocols. Starting with predicted functional germline variants obtained through who...

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Udgivet i:Oncotarget
Main Authors: Abaji, Rachid, Gagné, Vincent, Xu, Chang Jiang, Spinella, Jean-François, Ceppi, Francesco, Laverdière, Caroline, Leclerc, Jean-Marie, Sallan, Stephen E., Neuberg, Donna, Kutok, Jeffery L., Silverman, Lewis B., Sinnett, Daniel, Krajinovic, Maja
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546438/
https://ncbi.nlm.nih.gov/pubmed/28574850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17959
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