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Direct Synthesis of β-Aminoenals through Reaction of 1,2,3-Triazine with Secondary Amines
Simple and direct nucleophilic addition of secondary amines, including imidazole, to 1,2,3-triazine under mild reaction conditions (THF, 25–65 °C, 12–48 h), requiring no additives, cleanly provides β-aminoenals 4 in good yields (21 examples, 31–79%). The reaction proceeds by amine nucleophilic addit...
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| Publicado en: | Org Lett |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5546251/ https://ncbi.nlm.nih.gov/pubmed/28657329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b01543 |
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