Disease Model Discovery from 3,328 Gene Knockouts by The International Mouse Phenotyping Consortium

Although next generation sequencing has revolutionised the ability to associate variants with human diseases, diagnostic rates and development of new therapies are still limited by our lack of knowledge of function and pathobiological mechanism for most genes. To address this challenge, the Internat...

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Vydáno v:Nat Genet
Hlavní autoři: Meehan, Terrence F., Conte, Nathalie, West, David B., Jacobsen, Julius O., Mason, Jeremy, Warren, Jonathan, Chen, Chao-Kung, Tudose, Ilinca, Relac, Mike, Matthews, Peter, Karp, Natasha, Santos, Luis, Fiegel, Tanja, Ring, Natalie, Westerberg, Henrik, Greenaway, Simon, Sneddon, Duncan, Morgan, Hugh, Codner, Gemma F, Stewart, Michelle E, Brown, James, Horner, Neil, Haendel, Melissa, Washington, Nicole, Mungall, Christopher J., Reynolds, Corey L, Gallegos, Juan, Gailus-Durner, Valerie, Sorg, Tania, Pavlovic, Guillaume, Bower, Lynette R, Moore, Mark, Morse, Iva, Gao, Xiang, Tocchini-Valentini, Glauco P, Obata, Yuichi, Cho, Soo Young, Seong, Je Kyung, Seavitt, John, Beaudet, Arthur L., Dickinson, Mary E., Herault, Yann, Wurst, Wolfgang, de Angelis, Martin Hrabe, Lloyd, K.C. Kent, Flenniken, Ann M, Nutter, Lauryl MJ, Newbigging, Susan, McKerlie, Colin, Justice, Monica J., Murray, Stephen A., Svenson, Karen L., Braun, Robert E., White, Jacqueline K., Bradley, Allan, Flicek, Paul, Wells, Sara, Skarnes, William C., Adams, David J., Parkinson, Helen, Mallon, Ann-Marie, Brown, Steve D.M., Smedley, Damian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546242/
https://ncbi.nlm.nih.gov/pubmed/28650483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3901
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