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The human mitochondrial single-stranded DNA-binding protein displays distinct kinetics and thermodynamics of DNA binding and exchange

The human mitochondrial ssDNA-binding protein (mtSSB) is a homotetrameric protein, involved in mtDNA replication and maintenance. Although mtSSB is structurally similar to SSB from Escherichia coli (EcoSSB), it lacks the C-terminal disordered domain, and little is known about the biophysics of mtSSB...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Qian, Yufeng, Johnson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546044/
https://ncbi.nlm.nih.gov/pubmed/28615444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.791392
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