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Effect of APOE Genotype on Synaptic Proteins in Earlier Adult Life

BACKGROUND: Possession of APOE ɛ4 is a strong risk factor for late-onset Alzheimer’s disease and is associated with loss of synaptic proteins in the elderly even in the absence of Alzheimer’s disease. OBJECTIVE: We hypothesized that ɛ4 allele possession in non-demented adults aged under-75 would als...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Alzheimers Dis
Hauptverfasser: Sinclair, Lindsey I., Love, Seth
Format: Artigo
Sprache:Inglês
Veröffentlicht: IOS Press 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545905/
https://ncbi.nlm.nih.gov/pubmed/28731446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-170316
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