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Dynamic Modulation of Binding Affinity as a Mechanism for Regulating Interferon Signaling
How structural dynamics affects cytokine signaling is under debate. Here, we investigated the dynamics of the type I interferon (IFN) receptor, IFNAR1, and its effect on signaling upon binding IFN and IFNAR2 using a combination of structure-based mechanistic studies, in situ binding and gene inducti...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5545807/ https://ncbi.nlm.nih.gov/pubmed/28648616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.06.011 |
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