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The molecular basis for differential type I interferon signaling

Type I interferons (IFN-1) are cytokines that affect the expression of thousands of genes, resulting in profound cellular changes. IFN-1 activates the cell by dimerizing its two-receptor chains, IFNAR1 and IFNAR2, which are expressed on all nucleated cells. Despite a similar mode of binding, the dif...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Autor principal: Schreiber, Gideon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418031/
https://ncbi.nlm.nih.gov/pubmed/28289098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R116.774562
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