Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

Aberrant NMDA receptor (NMDAR) activity contributes to several neurological disorders, but direct antagonism is poorly tolerated therapeutically. The GluN2B cytoplasmic C-terminal domain (CTD) represents an alternative therapeutic target since it potentiates excitotoxic signaling. The key GluN2B CTD...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: McQueen, Jamie, Ryan, Tomás J, McKay, Sean, Marwick, Katie, Baxter, Paul, Carpanini, Sarah M, Wishart, Thomas M, Gillingwater, Thomas H, Manson, Jean C, Wyllie, David J A, Grant, Seth G N, McColl, Barry W, Komiyama, Noboru H, Hardingham, Giles E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544426/
https://ncbi.nlm.nih.gov/pubmed/28731405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17161
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