TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner

Antagonists that are sufficiently selective to preferentially block GluN2A-containing N-methyl-d-aspartate receptors (NMDARs) over GluN2B-containing NMDARs are few in number. In this study we describe a pharmacological characterization of 3-chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl...

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Hlavní autoři: Edman, S., McKay, S., MacDonald, L.J., Samadi, M., Livesey, M.R., Hardingham, G.E., Wyllie, D.J.A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Pergamon Press 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384000/
https://ncbi.nlm.nih.gov/pubmed/22579927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.04.027
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