BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

Despite current standard of care, the average 5-year mortality after an initial diagnosis of heart failure (HF) is about 40%, reflecting an urgent need for new therapeutic approaches. Previous studies demonstrated that the epigenetic reader protein bromodomain-containing protein 4 (BRD4), an emergin...

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Publicado no:Sci Transl Med
Main Authors: Duan, Qiming, McMahon, Sarah, Anand, Priti, Shah, Hirsh, Thomas, Sean, Salunga, Hazel T., Huang, Yu, Zhang, Rongli, Sahadevan, Aarathi, Lemieux, Madeleine E., Brown, Jonathan D., Srivastava, Deepak, Bradner, James E., McKinsey, Timothy A., Haldar, Saptarsi M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544253/
https://ncbi.nlm.nih.gov/pubmed/28515341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aah5084
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