TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy

Myocardial atrophy is a wasting of cardiac muscle due to hemodynamic unloading. Doxorubicin is a highly effective anticancer agent but also induces myocardial atrophy through a largely unknown mechanism. Here, we demonstrate that inhibiting transient receptor potential canonical 3 (TRPC3) channels a...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Shimauchi, Tsukasa, Numaga-Tomita, Takuro, Ito, Tomoya, Nishimura, Akiyuki, Matsukane, Ryosuke, Oda, Sayaka, Hoka, Sumio, Ide, Tomomi, Koitabashi, Norimichi, Uchida, Koji, Sumimoto, Hideki, Mori, Yasuo, Nishida, Motohiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543921/
https://ncbi.nlm.nih.gov/pubmed/28768915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93358
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