Preclinical immunoPET/CT imaging using Zr-89-labeled anti-PD-L1 monoclonal antibody for assessing radiation-induced PD-L1 upregulation in head and neck cancer and melanoma

Radiation therapy (RT) can induce upregulation of programmed death ligand 1 (PD-L1) on tumor cells or myeloid cells, which may affect response to PD-1-based immunotherapy. PD-L1 upregulation during RT is a dynamic process that has been difficult to monitor during treatment. The aim of this study was...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Kikuchi, Masahiro, Clump, David A., Srivastava, Raghvendra M., Sun, Lingyi, Zeng, Dexing, Diaz-Perez, Julio A., Anderson, Carolyn J., Edwards, W. Barry, Ferris, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543907/
https://ncbi.nlm.nih.gov/pubmed/28811971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1329071
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