Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site

A majority of cutaneous melanomas show activating mutations in the NRAS or BRAF proto‐oncogenes, components of the Ras‐Raf‐Mek‐Erk signal transduction pathway. Consistent data demonstrate the early appearance, in a mutually exclusive manner, of these mutations. The purpose of this paper is to summar...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Platz, Anton, Egyhazi, Suzanne, Ringborg, Ulrik, Hansson, Johan
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2007
Subjects:
Reviews
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543839/
https://ncbi.nlm.nih.gov/pubmed/19383313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2007.12.003
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