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Mutation of the inhibitory ethanol site in GABA(A) ρ1 receptors promotes tolerance to ethanol-induced motor incoordination
Genes encoding the ρ1/2 subunits of GABA(A) receptors have been associated with alcohol (ethanol) dependence in humans, and ρ1 was also shown to regulate some of the behavioral effects of ethanol in animal models. Ethanol inhibits GABA-mediated responses in wild-type (WT) ρ1, but not ρ1(T6’Y) mutant...
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| Veröffentlicht in: | Neuropharmacology |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5543808/ https://ncbi.nlm.nih.gov/pubmed/28623169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.06.013 |
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