Mutation of the inhibitory ethanol site in GABA(A) ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

Genes encoding the ρ1/2 subunits of GABA(A) receptors have been associated with alcohol (ethanol) dependence in humans, and ρ1 was also shown to regulate some of the behavioral effects of ethanol in animal models. Ethanol inhibits GABA-mediated responses in wild-type (WT) ρ1, but not ρ1(T6’Y) mutant...

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Pubblicato in:Neuropharmacology
Autori principali: Blednov, Yuri A., Borghese, Cecilia M., Ruiz, Carlos I., Cullins, Madeline A., Da Costa, Adriana, Osterndorff-Kahanek, Elizabeth A., Homanics, Gregg E., Harris, R. Adron
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543808/
https://ncbi.nlm.nih.gov/pubmed/28623169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.06.013
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