Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

Elimination of early-formed redundant synapses during postnatal development is essential for functional neural circuit formation. Purkinje cells (PCs) in the neonatal cerebellum are innervated by multiple climbing fibers (CFs). A single CF is strengthened whereas the other CFs are eliminated in each...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Choo, Myeongjeong, Miyazaki, Taisuke, Yamazaki, Maya, Kawamura, Meiko, Nakazawa, Takanobu, Zhang, Jianling, Tanimura, Asami, Uesaka, Naofumi, Watanabe, Masahiko, Sakimura, Kenji, Kano, Masanobu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543168/
https://ncbi.nlm.nih.gov/pubmed/28775326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00260-w
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