Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures

Cancer is a disease of subverted regulatory pathways. In this paper, we reconstruct the regulatory network around E2F, a family of transcription factors whose deregulation has been associated to cancer progression, chemoresistance, invasiveness, and metastasis. We integrate gene expression profiles...

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Udgivet i:Nat Commun
Main Authors: Khan, Faiz M., Marquardt, Stephan, Gupta, Shailendra K., Knoll, Susanne, Schmitz, Ulf, Spitschak, Alf, Engelmann, David, Vera, Julio, Wolkenhauer, Olaf, Pützer, Brigitte M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543083/
https://ncbi.nlm.nih.gov/pubmed/28775339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00268-2
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