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Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
Omecamtiv mecarbil is a selective, small-molecule activator of cardiac myosin that is being developed as a potential treatment for heart failure with reduced ejection fraction. Here we determine the crystal structure of cardiac myosin in the pre-powerstroke state, the most relevant state suggested b...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5543065/ https://ncbi.nlm.nih.gov/pubmed/28775348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00176-5 |
| Oznake: |
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