Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR(mt) to promote metastasis

By causing mitochondrial DNA (mtDNA) mutations and oxidation of mitochondrial proteins, reactive oxygen species (ROS) leads to perturbations in mitochondrial proteostasis. Several studies have linked mtDNA mutations to metastasis of cancer cells but the nature of the mtDNA species involved remains u...

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Bibliografiska uppgifter
I publikationen:Oncogene
Huvudupphovsmän: Kenny, T C, Hart, P, Ragazzi, M, Sersinghe, M, Chipuk, J, Sagar, M A K, Eliceiri, K W, LaFramboise, T, Grandhi, S, Santos, J, Riar, A K, Papa, L, D'Aurello, M, Manfredi, G, Bonini, M G, Germain, D
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542861/
https://ncbi.nlm.nih.gov/pubmed/28368421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.52
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