Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR(mt) to promote metastasis

By causing mitochondrial DNA (mtDNA) mutations and oxidation of mitochondrial proteins, reactive oxygen species (ROS) leads to perturbations in mitochondrial proteostasis. Several studies have linked mtDNA mutations to metastasis of cancer cells but the nature of the mtDNA species involved remains u...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Kenny, T C, Hart, P, Ragazzi, M, Sersinghe, M, Chipuk, J, Sagar, M A K, Eliceiri, K W, LaFramboise, T, Grandhi, S, Santos, J, Riar, A K, Papa, L, D'Aurello, M, Manfredi, G, Bonini, M G, Germain, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542861/
https://ncbi.nlm.nih.gov/pubmed/28368421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.52
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