The C-2 derivatives of Salvinorin A, ethoxymethyl ether Sal B and β-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects

RATIONALE: Kappa-opioid receptor (KOPr) agonists have pre-clinical anti-cocaine and analgesic effects. However, side-effects including sedation, dysphoria, aversion, anxiety and depression limit their therapeutic development. The unique structure of Salvinorin A has been used to develop longer-actin...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Ewald, Amy W.M., Bosch, Peter J., Culverhouse, Aimee, Crowley, Rachel Saylor, Neuenswander, Benjamin, Prisinzano, Thomas E., Kivell, Bronwyn M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542847/
https://ncbi.nlm.nih.gov/pubmed/28536865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-017-4637-2
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