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Targeting the unfolded protein response in cancer

Cancer cells are exposed to various intrinsic and extrinsic factors that disrupt protein homeostasis, producing endoplasmic reticulum (ER) stress. To cope with these situations, cancer cells evoke a highly conserved adaptive mechanism called the unfolded protein response (UPR) to restore the ER home...

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Detalles Bibliográficos
Publicado en:Pharmacol Res
Autores principales: Ojha, Rani, Amaravadi, Ravi K
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542584/
https://ncbi.nlm.nih.gov/pubmed/28396092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2017.04.003
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