ARID1B alterations identify aggressive tumors in neuroblastoma

Targeted panel sequencing was performed to determine molecular targets and biomarkers in 72 children with neuroblastoma. Frequent genetic alterations were detected in ALK (16.7%), BRCA1 (13.9%), ATM (12.5%), and PTCH1 (11.1%) in an 83-gene panel. Molecular targets for targeted therapy were identifie...

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Udgivet i:Oncotarget
Main Authors: Lee, Soo Hyun, Kim, Jung-Sun, Zheng, Siyuan, Huse, Jason T., Bae, Joon Seol, Lee, Ji Won, Yoo, Keon Hee, Koo, Hong Hoe, Kyung, Sungkyu, Park, Woong-Yang, Sung, Ki W.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542239/
https://ncbi.nlm.nih.gov/pubmed/28521285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17500
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