Cargando...

Thalassemia due to a mutation in the cleavage-polyadenylation signal of the human beta-globin gene.

A beta-globin gene cloned from a person with beta-thalassemia contained a T----C substitution within the conserved sequence AATAAA that forms a portion of the recognition signal for endonucleolytic cleavage and polyadenylation of primary mRNA transcripts. By Northern blot analysis a novel beta-globi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Orkin, S H, Cheng, T C, Antonarakis, S E, Kazazian, H H
Formato: Artigo
Lenguaje:Inglês
Publicado: 1985
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC554207/
https://ncbi.nlm.nih.gov/pubmed/4018033
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!