Chemotherapeutic xCT inhibitors sorafenib and erastin unraveled with the synaptic optogenetic function analysis tool

In the search for new potential chemotherapeutics, the compounds’ toxicity to healthy cells is an important factor. The brain with its functional units, the neurons, is especially endangered during the radio- and chemotherapeutic treatment of brain tumors. The effect of the potential compounds not o...

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Bibliographic Details
Published in:Cell Death Discov
Main Authors: Dahlmanns, Marc, Yakubov, Eduard, Chen, Daishi, Sehm, Tina, Rauh, Manfred, Savaskan, Nicolai, Wrosch, Jana Katharina
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541984/
https://ncbi.nlm.nih.gov/pubmed/28835855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.30
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