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Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation

The spindle is a dynamic structure that changes its architecture and size in response to biochemical and physical cues. For example, a simple physical change, cell confinement, can trigger centrosome separation and increase spindle steady-state length at metaphase. How this occurs is not understood,...

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Publicado en:Mol Biol Cell
Main Authors: Guild, Joshua, Ginzberg, Miriam B., Hueschen, Christina L., Mitchison, Timothy J., Dumont, Sophie
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541847/
https://ncbi.nlm.nih.gov/pubmed/28468979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-03-0171
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