Lysosomal Degradation is Required for Sustained Phagocytosis of Bacteria by Macrophages

Clearance of bacteria by macrophages involves internalization of the microorganisms into phagosomes, which are then delivered to endolysosomes for enzymatic degradation. These spatiotemporally segregated processes are not known to be functionally coupled. Here, we show that lysosomal degradation of...

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Publicado en:Cell Host Microbe
Main Authors: Wong, Ching-On, Gregory, Steven, Hu, Hongxiang, Chao, Yufang, Sepúlveda, Victoria E., He, Yuchun, Li-Kroeger, David, Goldman, William E., Bellen, Hugo J., Venkatachalam, Kartik
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540652/
https://ncbi.nlm.nih.gov/pubmed/28579255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.05.002
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