Lysosomal Degradation is Required for Sustained Phagocytosis of Bacteria by Macrophages

Clearance of bacteria by macrophages involves internalization of the microorganisms into phagosomes, which are then delivered to endolysosomes for enzymatic degradation. These spatiotemporally segregated processes are not known to be functionally coupled. Here, we show that lysosomal degradation of...

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Veröffentlicht in:Cell Host Microbe
Hauptverfasser: Wong, Ching-On, Gregory, Steven, Hu, Hongxiang, Chao, Yufang, Sepúlveda, Victoria E., He, Yuchun, Li-Kroeger, David, Goldman, William E., Bellen, Hugo J., Venkatachalam, Kartik
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540652/
https://ncbi.nlm.nih.gov/pubmed/28579255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.05.002
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