Lysosomal Degradation is Required for Sustained Phagocytosis of Bacteria by Macrophages

Clearance of bacteria by macrophages involves internalization of the microorganisms into phagosomes, which are then delivered to endolysosomes for enzymatic degradation. These spatiotemporally segregated processes are not known to be functionally coupled. Here, we show that lysosomal degradation of...

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Vydáno v:Cell Host Microbe
Hlavní autoři: Wong, Ching-On, Gregory, Steven, Hu, Hongxiang, Chao, Yufang, Sepúlveda, Victoria E., He, Yuchun, Li-Kroeger, David, Goldman, William E., Bellen, Hugo J., Venkatachalam, Kartik
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540652/
https://ncbi.nlm.nih.gov/pubmed/28579255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.05.002
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