Metabolic Regulation of Gene Expression by Histone Lysine β-hydroxybutyrylation

Here we report the identification and verification of a β-hydroxybutyrate-derived protein modification, lysine β-hydroxybutyrylation (Kbhb), as a new type of histone mark. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells, and in livers fr...

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Vydáno v:Mol Cell
Hlavní autoři: Xie, Zhongyu, Zhang, Di, Chung, Dongjun, Tang, Zhanyun, Huang, He, Dai, Lunzhi, Qi, Shankang, Li, Jingya, Colak, Gozde, Chen, Yue, Xia, Chunmei, Peng, Chao, Ruan, Haibin, Kirkey, Matt, Wang, Danli, Jensen, Lindy M., Kwon, Oh Kwang, Lee, Sangkyu, Pletcher, Scott D., Tan, Minjia, Lombard, David B., White, Kevin P., Zhao, Hongyu, Li, Jia, Roeder, Robert G., Xiaoyong, Yang, Zhao, Yingming
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540445/
https://ncbi.nlm.nih.gov/pubmed/27105115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.036
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