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Targeting pseudokinase TRIB3 brings about a new therapeutic option for acute promyelocytic leukemia
Pseudokinase tribbles (Trib) family, Trib1 and Trib2, but not Trib3, act as oncogene to drive acute leukemia by destabilizing the myeloid transcription factor CCAAT/enhancer-binding protein α (C/EBPα) and inhibiting myeloid differentiation. A recent study identifies pseudokinase TRIB3 as an importan...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Cell Oncol |
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| Κύριοι συγγραφείς: | , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Taylor & Francis
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5540211/ https://ncbi.nlm.nih.gov/pubmed/28868348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1337547 |
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