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Targeting pseudokinase TRIB3 brings about a new therapeutic option for acute promyelocytic leukemia
Pseudokinase tribbles (Trib) family, Trib1 and Trib2, but not Trib3, act as oncogene to drive acute leukemia by destabilizing the myeloid transcription factor CCAAT/enhancer-binding protein α (C/EBPα) and inhibiting myeloid differentiation. A recent study identifies pseudokinase TRIB3 as an importan...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5540211/ https://ncbi.nlm.nih.gov/pubmed/28868348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1337547 |
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