Combined Blockade of T Cell Immunoglobulin and Mucin Domain 3 and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Results in Durable Therapeutic Efficacy in Mice with Intracranial Gliomas

BACKGROUND: Glioblastoma multiforme (GBM) evades immune surveillance by inducing immunosuppression via receptor-ligand interactions between immune checkpoint molecules. T cell immunoglobulin and mucin domain 3 (Tim-3) is a key checkpoint receptor responsible for exhaustion and dysfunction of T cells...

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Bibliographische Detailangaben
Veröffentlicht in:Med Sci Monit
Hauptverfasser: Li, Jinhu, Liu, Xiaodong, Duan, Yijun, Liu, Yueting, Wang, Hongqin, Lian, Shizhong, Zhuang, Guotao, Fan, Yimin
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Scientific Literature, Inc. 2017
Schlagworte:
Animal Study
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540004/
https://ncbi.nlm.nih.gov/pubmed/28736431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.903098
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