p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis

Malignant glioma is a highly aggressive brain tumor with a poor prognosis. Chemotherapy has been observed to prolong overall survival rate and temozolomide (TMZ), a promising chemotherapeutic agent for treating glioblastoma (GBM), possesses the most effective clinical activity at present, although d...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: MIAO, WANG, LIU, XIAODONG, WANG, HONGQIN, FAN, YIMIN, LIAN, SHIZHONG, YANG, XIN, WANG, XINXING, GUO, GENG, LI, QICHAO, WANG, SIFEI
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394929/
https://ncbi.nlm.nih.gov/pubmed/25625235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2015.3255
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