Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.

We have studied the mechanism of a transforming growth factor-beta (TGF-beta)-stimulated production of type-1 plasminogen activator inhibitor (PAI-1) in WI-38 human lung fibroblasts. TGF-beta causes an early increase in the PAI-1 mRNA level which reaches a maximal 50-fold enhancement after 8 h. Bloc...

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Autori principali: Lund, L R, Riccio, A, Andreasen, P A, Nielsen, L S, Kristensen, P, Laiho, M, Saksela, O, Blasi, F, Danø, K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1987
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC553930/
https://ncbi.nlm.nih.gov/pubmed/3111844
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