Hypomethylation of CNTFRα is associated with proliferation and poor prognosis in lower grade gliomas

Ciliary neurotrophic factor receptor α subunit (CNTFRα) and CNTF play important roles in neuron survival, glial differentiation and brain tumor growth. However, the molecular mechanisms of CNTFRα regulation and its clinical significance in glioma remain largely unknown. Here, we found CNTFRα was ove...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fan, Kun, Wang, Xiaowen, Zhang, Jingwen, Ramos, Romela Irene, Zhang, Haibo, Li, Chunjie, Ye, Dan, Kang, Jiansheng, Marzese, Diego M., Hoon, Dave S. B., Hua, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539284/
https://ncbi.nlm.nih.gov/pubmed/28765641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07124-9
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