Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

Constitutive depletion of p21-activated kinase 4 (PAK4) in the mouse causes embryonic lethality associated with heart and brain defects. Given that conventional gene depletion of PAK1 or PAK3 caused functional deficits in the mouse pancreas, while gene depletion of PAK5 or PAK6 did not, we asked if...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Zhao, Miao, Rabieifar, Parisa, Costa, Tânia D. F., Zhuang, Ting, Minden, Audrey, Löhr, Matthias, Heuchel, Rainer, Strömblad, Staffan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539201/
https://ncbi.nlm.nih.gov/pubmed/28765528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07322-5
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