Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT(3) receptor expression via acetate production

Serotonin [5-hydroxytryptamine (5-HT)], an important neurotransmitter and a paracrine messenger in the gastrointestinal tract, regulates intestinal secretion by its action primarily on 5-HT(3) and 5-HT(4) receptors. Recent studies highlight the role of gut microbiota in 5-HT biosynthesis. In this st...

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Udgivet i:Am J Physiol Gastrointest Liver Physiol
Main Authors: Bhattarai, Yogesh, Schmidt, Bradley A., Linden, David R., Larson, Eric D., Grover, Madhusudan, Beyder, Arthur, Farrugia, Gianrico, Kashyap, Purna C.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538830/
https://ncbi.nlm.nih.gov/pubmed/28408644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00448.2016
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