Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly

SUV39H is the major histone H3 lysine 9 (H3K9)-specific methyltransferase that targets pericentric regions and is crucial for assembling silent heterochromatin. SUV39H recognizes trimethylated H3K9 (H3K9me3) via its chromodomain (CD), and enriched H3K9me3 allows SUV39H to target specific chromosomal...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Shirai, Atsuko, Kawaguchi, Takayuki, Shimojo, Hideaki, Muramatsu, Daisuke, Ishida-Yonetani, Mayumi, Nishimura, Yoshifumi, Kimura, Hiroshi, Nakayama, Jun-ichi, Shinkai, Yoichi
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Genes and Chromosomes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538823/
https://ncbi.nlm.nih.gov/pubmed/28760201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25317
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