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Defining the target and the effect of imatinib on the filarial c-Abl homologue
BACKGROUND: Previously we demonstrated the micro- and macrofilaricidal properties of imatinib in vitro. Here we use electron and multiphoton microscopy to define the target of imatinib in the adult and microfilarial stages of Brugia malayi and assess the effects of pharmacologically relevant levels...
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| Pubblicato in: | PLoS Negl Trop Dis |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538754/ https://ncbi.nlm.nih.gov/pubmed/28727765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005690 |
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