Suppression of Akt1- β-catenin pathway in advanced prostate cancer promotes TGFβ1-mediated epithelial to mesenchymal transition and metastasis

Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the genetic ablation or pharmacologic...

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Vydáno v:Cancer Lett
Hlavní autoři: Gao, Fei, Alwhaibi, Abdulrahman, Sabbineni, Harika, Verma, Arti, Eldahshan, Wael, Somanath, Payaningal R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538588/
https://ncbi.nlm.nih.gov/pubmed/28602980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.05.028
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