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Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus

Anorexia is a common manifestation of chronic diseases, including cancer. Here we investigate the contribution to cancer anorexia made by calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) that transmit anorexic signals. We show that CGRP(PBN) neurons are activated in m...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Campos, Carlos A., Bowen, Anna J., Han, Sung, Wisse, Brent E., Palmiter, Richard D., Schwartz, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538581/
https://ncbi.nlm.nih.gov/pubmed/28581479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4574
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