GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

The eIF4E homologous protein (4EHP) is thought to repress translation by competing with eIF4E for binding to the 5′ cap structure of specific mRNAs to which it is recruited through interactions with various proteins, including the GRB10-interacting GYF (glycine–tyrosine–phenylalanine domain) protein...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Peter, Daniel, Weber, Ramona, Sandmeir, Felix, Wohlbold, Lara, Helms, Sigrun, Bawankar, Praveen, Valkov, Eugene, Igreja, Cátia, Izaurralde, Elisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538437/
https://ncbi.nlm.nih.gov/pubmed/28698298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.299420.117
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