Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies

Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express a bispecific single‐chain antibody, secreted from infected tumo...

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Dades bibliogràfiques
Publicat a:EMBO Mol Med
Autors principals: Freedman, Joshua D, Hagel, Joachim, Scott, Eleanor M, Psallidas, Ioannis, Gupta, Avinash, Spiers, Laura, Miller, Paul, Kanellakis, Nikolaos, Ashfield, Rebecca, Fisher, Kerry D, Duffy, Margaret R, Seymour, Leonard W
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538299/
https://ncbi.nlm.nih.gov/pubmed/28634161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707567
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